Adapalene Gel

Overview

Adapalene Gel is a topical medicine primarily used to treat acne vulgaris. It belongs to the family of retinoids and is derived from vitamin A.

This gel works by reducing inflammation, unclogging pores, and restoring normal skin cell turnover. The most common strengths are 0.1% (available over-the-counter) and 0.3% (available with a prescription).

Popular brand names include Differin, Adaferin, and Epiduo (when combined with benzoyl peroxide).

Description

• Chemical Name: 6-[3-(1-adamantyl)-4-methoxyphenyl]No. 2 naphthoic acid

• Formulation: Gel, cream, lotion, and solution

• Concentrations: 0.1% and 0.3%

• Medicinal Class: Retinoid-like compound

• Mechanism of Action: Regulates keratinization and reduces inflammation by binding to retinoic acid receptors (RAR-β and RAR-γ).

Uses of Adapalene Gel

• Treatment of acne vulgaris – reduces blackheads, whiteheads, pimples, and inflamed acne lesions.

• Prevents clogged pores – promotes natural cell turnover.

• Reduces inflammation – decreases redness, swelling, and irritation.

• Improves skin texture – promotes clearer, smoother, and more even-toned skin.

Indications:

• Comedonal acne (whiteheads, blackheads)

• Papules, pustules, and inflamed acne

• Off-label: post-inflammatory hyperpigmentation, fine lines, wrinkles, and rough skin texture

Benefits

• Normalizes skin cell cycle, preventing pore blockage.

• Reduces development of new acne lesions.

• Improves overall skin texture.

• Better tolerated than older retinoids like tretinoin.

Dosage Guidelines

• Direction for Use: Apply a thin layer once daily in the evening to clean, dry skin. Avoid eyes, lips, and mucous membranes.

• Dosage:

  • 0.1% Gel – recommended for sensitive skin or first-time users

  • 0.3% Gel – prescribed when lower strength is insufficient

• Initial flare-up (“purging”) may occur during the first few weeks. Visible improvement usually appears within 8–12 weeks.

Do Not Use If:

• Allergic to Adapalene or its ingredients

• Skin is broken, sunburned, or eczematous

• Pregnant, unless prescribed

• Children under 12 years old (unless directed by a doctor)

Drug Interactions

• Safe to use with: Moisturizers (non-comedogenic), broad-spectrum sunscreen, benzoyl peroxide, or clindamycin (when prescribed).

• Avoid with: Other retinoids, alpha hydroxy acids, glycolic acid, salicylic acid, sulfur, resorcinol, or harsh cleansers/alcohol-based products (unless advised by a doctor).

Safety Advice & Precautions

• May cause redness, dryness, scaling, and itching in the beginning.

• Skin becomes more sensitive to sunlight – always apply sunscreen.

• Avoid tanning beds, excessive sun exposure, or waxing on treated areas.

• If severe irritation occurs, reduce frequency of use or temporarily stop.

General Instructions

• Wash face gently twice daily with a mild cleanser.

• Do not touch or squeeze acne lesions.

• Use oil-free/non-comedogenic skincare and makeup products.

• Drink sufficient water, eat a balanced diet, and manage stress.

Lifestyle & Diet Tips

• Reduce sugar, dairy, and high-glycemic foods.

• Eat fruits, vegetables, and omega-3-rich foods.

• Stay hydrated and get adequate sleep.

• Avoid over-washing or scrubbing skin harshly.

Comparison with Other Acne Treatments

Adapalene vs Tretinoin:

• More stable in light and can be combined with benzoyl peroxide.

• Less irritating and better tolerated, especially for sensitive skin.

• Works slightly slower but suitable for long-term use.

Adapalene vs Benzoyl Peroxide:

• Adapalene clears pores and regulates skin turnover.

• Benzoyl Peroxide kills acne-causing bacteria but may cause dryness.

• Combination (e.g., Epiduo) provides highly effective acne management.

Storage Instructions

• Store below 25°C, away from heat, humidity, and direct sunlight.

• Keep container tightly closed after each use.

• Keep out of reach of children and pets.

• Use before the expiration date.

Buy Adapalene Gel

Onco India International is a trusted manufacturer, supplier, and exporter of Adapalene Gel in different concentrations (0.1% and 0.3%).
If you are looking for high-quality Adapalene Gel for acne treatment, you can rely on Onco India International for genuine and effective dermatology formulations.