What is Clobetasol Propionate Cream?

Clobetasol Propionate Cream is a super-potent corticosteroid used for treating severe skin conditions that do not respond to weaker corticosteroids.

It is available in several forms such as cream, ointment, lotion, gel, spray, foam, and shampoo. Being a Class I corticosteroid, it is among the strongest topical steroids available.

This medication is indicated for skin disorders that present with inflammation, redness, swelling, and itching and should be used only under strict medical supervision for short durations.

Description

• Drug Class: Topical corticosteroid (Class I – Super potent)

• Generic Name: Clobetasol Propionate

• Concentration: 0.05% w/w

• Formulations: Cream, ointment, lotion, gel, spray, foam, and shampoo

Uses of Clobetasol Propionate Cream

• Redness (erythema)

• Swelling (edema)

• Itching (pruritus)

• Scaling or skin thickening

• Relief from flare-up discomfort

Indications

Clobetasol Propionate Cream is prescribed for the short-term management of:

• Psoriasis

• Atopic dermatitis

• Lichen planus

• Lichen sclerosis

• Eczema (severe forms)

• Seborrheic dermatitis

• Skin allergies

Drug Interactions

• Other corticosteroids: May enhance systemic steroid effects.

• CYP3A4 inhibitors: Reduce metabolism, increasing drug activity.

• Immunosuppressive agents: May increase infection or adrenal suppression risk.

• Vaccinations: May reduce immune response to live vaccines if systemic absorption occurs.

Benefits

• Fast and powerful control of skin inflammation

• Effective relief from redness, itching, and burning

• Rapid clearance of scaly plaques in psoriasis

• Reduces the need for systemic steroids

• Improves quality of life in chronic skin diseases

Side Effects

• Burning or stinging sensation

• Dryness or cracking of skin

• Irritation or redness

• Skin thinning (atrophy)

• Stretch marks with long-term use

How It Works

Clobetasol Propionate acts by binding to glucocorticoid receptors in the skin cells, reducing the production of inflammatory chemicals such as prostaglandins and leukotrienes.

It also causes vasoconstriction (narrowing of blood vessels), lowering swelling and discomfort. Its anti-inflammatory and immune-suppressive actions make it highly effective for severe skin conditions.

Dosage Guidelines

• Adults: Apply once or twice daily in a thin layer.

• Duration: Do not use longer than 2 consecutive weeks.

• Max Weekly Dose: 50 g/week.

• Children: Not recommended under 12 years unless under specialist care.

How to Use:

1. Clean and dry the affected area.

2. Apply a pea-sized amount in a thin layer.

3. Gently massage until absorbed.

4. Wash hands after application (unless treating them).

5. Avoid covering or bandaging unless advised.

When Not to Use

• Fungal, viral, or bacterial infections (unless combined therapy prescribed)

• Rosacea or acne

• Perioral dermatitis

• Hypersensitivity to corticosteroids

Safety Advice & Precautions

• Use the lowest effective dose for the shortest time.

• Avoid applying on large body surfaces.

• Monitor for adrenal suppression (HPA axis suppression).

• Use with caution in diabetic patients (possible rise in blood sugar).

• Not recommended for facial application or long-term use.

Lifestyle & Skincare Tips

• Use gentle, fragrance-free cleansers and moisturizers.

• Avoid triggers like harsh soaps, heat, and allergens.

• Wear soft, breathable clothing.

• Manage stress with yoga, meditation, or breathing exercises.

• Eat an anti-inflammatory diet (fruits, leafy greens, omega-3 rich foods).

• Stay hydrated.

Storage Instructions

• Store at 20°C to 25°C.

• Keep away from heat, sunlight, and moisture.

• Do not freeze.

• Keep out of reach of children.

Buy Clobetasol Propionate Cream

Onco India International is a trusted manufacturer, exporter, wholesaler, and supplier of high-quality Clobetasol Propionate Cream.

If you are looking for safe and effective Clobetasol Propionate Cream 0.05% w/w, feel free to contact Onco India International for bulk supply or export inquiries.