Alprostadil Lyophilised Injection – Onco India International

Overview
Alprostadil Lyophilised Injection is a prescription medication manufactured by Onco India International, used for the treatment of erectile dysfunction (ED) in men and for certain congenital heart conditions in newborns.

ED is a condition where men are unable to achieve or maintain an erection firm enough for intercourse. In infants, Alprostadil helps by keeping a vital blood vessel (ductus arteriosus) open before corrective heart surgery.

Alprostadil is a synthetic form of prostaglandin E1 (PGE1), a natural substance in the body that relaxes blood vessels and improves blood flow. The medicine is supplied as a freeze-dried (lyophilised) powder, which must be mixed with sterile liquid before use. It is administered either as an intracavernosal injection (into the penis) for ED, or as an intravenous infusion in newborns.

Description

• Packaged in a small sterile glass vial.

• Contains a white lyophilised powder to be reconstituted before administration.

• In ED: injected at the base or side of the penis.

• In infants: given intravenously in hospital under strict medical supervision.

• Acts quickly by relaxing smooth muscles and dilating blood vessels.

• Must be administered only under medical guidance. Some men may be trained to self-inject safely at home.

Uses / Indications

1. Erectile Dysfunction in Adult Men

   • Improves penile blood flow and induces erections.

   • Recommended for patients who do not respond to or cannot take oral ED drugs.

2. Congenital Heart Defects in Infants

   • Maintains ductus arteriosus patency before surgery.

   • Essential in critical congenital heart diseases to maintain oxygenated blood flow.

3. Diagnostic Use

   • Occasionally used in penile blood flow studies before surgery or advanced treatments.

Benefits

• Rapid onset: erection within 5–20 minutes.

• Useful in patients resistant to oral ED therapy.

• Allows greater control over timing of intercourse.

• In infants, life-saving role before corrective surgery.

• Localised effect with minimal systemic involvement.

Side Effects

Common:

• Pain, redness, or bruising at injection site.

• Warmth or tingling in penis.

• Mild bleeding post-injection.

• Temporary prolonged erection without pain.

Serious (seek urgent care):

• Priapism (erection lasting >4 hours with pain).

• Penile fibrosis (scarring, curvature from repeated injections at same site).

• Infection signs: swelling, pus, fever.

• Blood in urine or unusual penile discharge.

• Severe allergic reactions: rash, itching, breathing difficulty.

How It Works

• Alprostadil relaxes smooth muscles in blood vessel walls.

• Dilates penile arteries → increased blood flow → erection.

• Maintains erection long enough for intercourse.

• In infants, keeps ductus arteriosus open to ensure proper circulation until surgery.

Dosage Guidelines

• For Erectile Dysfunction (Adults):

  • Initial dose: 2.5–20 micrograms, adjusted gradually.

  • Max: 3 injections/week; minimum 24 hours between doses.

• For Infants (Congenital Heart Defects):

  • Dose calculated strictly based on infant’s weight and condition.

  • Administered only in hospital by trained medical staff.

 Overdosing may cause dangerous complications and must be avoided.

When Not to Use

• Men with sickle cell anaemia, leukaemia, or recurrent painful erections.

• Patients with penile implants or severe penile deformities.

• Pregnant or breastfeeding women must not handle or use the drug.

Drug Interactions

Avoid Combining With:

• Other ED medications (sildenafil, tadalafil, vardenafil).

• Nitrate drugs (used in angina/chest pain).

• Blood thinners (warfarin, heparin).

• Alcohol or recreational drugs (increase risk of side effects).

May Be Used With (under medical supervision):

• Diabetes medicines.

• Cholesterol-lowering drugs.

• Blood pressure medicines (monitor closely).

• Certain antibiotics.

Safety Advice

• Use only as prescribed by your doctor.

• Use sterile syringes and needles for every injection.

• Do not share medication or injection equipment.

• Rotate injection sites to avoid scarring.

• If your partner is pregnant, use a condom during intercourse.

• Avoid driving or heavy work if dizzy or weak after use.

Storage

• Store in a cool, dry place away from direct sunlight.

• Reconstituted solution must be used immediately or refrigerated (as directed).

• Do not freeze.

• Keep tightly sealed and out of reach of children.

• Discard expired or contaminated vials.

• Dispose used needles and vials in a proper sharps container.

Lifestyle Tips to Enhance Effectiveness

• Eat a heart-healthy diet: fruits, vegetables, whole grains.

• Stay hydrated, reduce alcohol intake.

• Stop smoking – improves vascular health.

• Exercise regularly to improve blood circulation.

• Manage stress with relaxation techniques.

Comparison with Other ED Treatments

• Faster onset (5–20 mins) than oral PDE5 inhibitors (30–60 mins).

• Suitable for men who cannot take ED pills (due to heart or blood pressure medications).

• Alternatives: vacuum devices, penile implants, or oral drugs.

• Each option has pros and cons; Alprostadil is highly effective for rapid results.

Precautions & Warnings

• Always disclose complete medical history before starting therapy.

• Avoid injecting at same site repeatedly.

• Stop treatment and consult doctor if painful/scarred erections occur.

• Never exceed prescribed frequency or dosage.

• Seek immediate help if erection >4 hours, chest pain, or severe dizziness occurs.

Onco India International – Commitment to Quality

Onco India International ensures the highest standards of safety, efficacy, and reliability in every vial of Alprostadil Lyophilised Injection. With rigorous quality control and adherence to global pharmaceutical norms, patients and healthcare providers can trust its effectiveness for both adult men with ED and newborns requiring cardiac support.