Tobramycin Sulphate

• Type: Aminoglycoside antibiotic

• Main Use: Treats bacterial infections, especially those caused by Gram-negative bacteria.

• Often available as eye drops, ointment, ear drops, or injection depending on the type of infection.

How It Works

• Tobramycin binds to bacterial ribosomes (30S subunit).

• This interferes with protein synthesis, stopping bacterial growth and eventually killing them.

• It is bactericidal (kills bacteria rather than just stopping their growth).

Common Uses

Eye/Ear Drops:

• Bacterial conjunctivitis (pink eye)

• Keratitis (corneal infection)

• Blepharitis (eyelid infection)

• Otitis externa (outer ear infection)

Injection Form (Hospital Use):

• Serious infections such as sepsis, pneumonia, urinary tract infections caused by resistant bacteria

• Often used in combination with other antibiotics for severe infections

Advantages

• Highly effective against Pseudomonas aeruginosa and other Gram-negative bacteria

• Works quickly due to its bactericidal action

• Available in multiple forms (drops, ointment, injectable) for flexibility

Possible Side Effects

Topical (Eye/Ear):

• Mild burning or stinging

• Temporary eye irritation or redness

• Rare allergic reaction

Systemic (Injection):

• Kidney toxicity (nephrotoxicity) if used for long periods

• Ear toxicity (ototoxicity) causing hearing loss or balance problems (rare but possible)

• Neuromuscular weakness (rare)

Precautions

• Use only for bacterial infections — not for viral or fungal infections.

• Avoid prolonged or unnecessary use to prevent bacterial resistance.

• In injection form, kidney function should be monitored during treatment.

• Keep dropper tip clean to avoid contamination of the medication.