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Human Rabies Immunoglobulin Vaccines Injection

Product/Composition Human Rabies Immunoglobulin Vaccines Injection
Form Injection
Strength 2ml
Production Capacity 1 Million Injection/Month
Therapeutic use Antiviral, Anti HIV
Package Insert/Leaflet Available upon request

INQUIRE ABOUT Human Rabies Immunoglobulin Vaccines Injection

Human Rabies Immunoglobulin (HRIG) Injection

  • Type: Passive immunization

  • Composition: Purified immunoglobulin (antibodies) derived from human plasma containing high titers of rabies-neutralizing antibodies

  • Form: Sterile solution for intramuscular (IM) injection, sometimes infiltrated directly into and around the wound

How It Works

  • HRIG provides immediate passive antibodies against the rabies virus.

  • These antibodies neutralize the virus at the site of entry before it can spread to the central nervous system.

  • Used as part of post-exposure prophylaxis (PEP) together with the rabies vaccine.

Common Uses

HRIG is given to individuals who have had:

  • Category III exposures (severe bites, scratches, contamination of mucous membrane with saliva from suspected rabid animal)

  • Category II exposures (moderate bites) if immediate vaccine-only response is considered insufficient

  • Any situation where immediate neutralizing antibodies are required before the person’s own immune system responds to the rabies vaccine

Administration

  • Dose: Typically 20 IU/kg body weight

  • As much of the dose as possible is infiltrated around the wound

  • Any remaining volume is injected intramuscularly at a site distant from rabies vaccine injection

  • Given only once at the beginning of post-exposure prophylaxis

Advantages

  • Provides immediate protection until the rabies vaccine can stimulate active immunity

  • Especially important for unvaccinated individuals after high-risk exposures

  • Reduces the risk of rabies, a disease that is almost always fatal once symptoms appear

Possible Side Effects

Mild/Temporary:

  • Local pain, redness, or swelling at injection site

  • Mild fever or malaise

Rare:

  • Allergic reactions (rash, itching)

  • Very rare anaphylactic reaction

Precautions

  • Must be used in combination with rabies vaccine, never as a substitute

  • Should be administered as soon as possible after exposure (preferably within 24 hours)

  • Avoid injecting HRIG and vaccine into the same anatomical site or syringe (they can interfere with each other’s action)