Ligustrazine Phosphate Lyophilized Injection is a parenteral formulation of ligustrazine (also known as tetramethylpyrazine), an alkaloid originally isolated from the traditional Chinese medicinal plant Ligusticum chuanxiong. It is prepared as a lyophilized (freeze-dried) powder for reconstitution prior to intravenous use.

Here are the main details:

1. Composition and Form:

• Active ingredient: Ligustrazine phosphate.

• Supplied as sterile lyophilized powder in vials.

• Reconstituted with sterile water or appropriate diluent, usually for intravenous infusion.

2. Mechanism of Action:

• Improves microcirculation and blood flow by inhibiting platelet aggregation and reducing blood viscosity.

• Promotes vasodilation by relaxing vascular smooth muscle.

• Provides antioxidant and anti-inflammatory effects, helping protect tissues from ischemia-reperfusion injury.

• May improve oxygen supply to tissues by enhancing hemorheology.

3. Indications (as used in clinical practice, especially in China):

• Cardiovascular disorders: angina pectoris, coronary heart disease, ischemic heart failure.

• Cerebrovascular diseases: ischemic stroke, cerebral thrombosis, transient ischemic attacks.

• Peripheral vascular disorders: arteriosclerosis obliterans, microcirculatory dysfunction.

• Sometimes used as supportive therapy in diabetic vascular complications.

4. Administration:

• Given as intravenous infusion after reconstitution and dilution.

• Dose and treatment duration depend on condition and physician’s protocol.

• Always used in controlled hospital or clinical settings.

5. Side Effects:

• Generally well tolerated, but possible: dizziness, flushing, headache.

• Gastrointestinal upset (nausea, vomiting).

• Hypotension due to vasodilation.

• Rare allergic or hypersensitivity reactions.

• Local irritation at injection site.

6. Contraindications:

• Known hypersensitivity to ligustrazine or related compounds.

• Severe hypotension or shock.

• Severe bleeding tendency or coagulation disorders.

7. Precautions:

• Use with caution in patients taking anticoagulants or antiplatelet agents (additive bleeding risk).

• Monitor blood pressure and coagulation parameters during therapy.

• Safety in pregnancy and lactation not well established.

8. Storage:

• Store vials in a cool, dry place, protected from light.

• Use reconstituted solution promptly or within the recommended stability period.