Mitotane Tablets are a prescription medicine that belongs to the class of adrenolytic agents. They are primarily used in the treatment of adrenal gland disorders, especially adrenal cancer.

Here are the key details:

• Main Use:

  • Treats adrenocortical carcinoma, a rare type of adrenal gland cancer.

  • Sometimes used to reduce hormone production in patients with overactive adrenal glands.

• How It Works: Mitotane selectively destroys adrenal cortex cells, reducing the production of certain hormones like cortisol. This helps control symptoms caused by excess hormone production and slows tumor growth.

• Administration: Taken orally, usually in divided doses with meals as directed by a doctor. Dosage is individualized based on patient response and hormone levels.

• Common Side Effects: Nausea, vomiting, loss of appetite, fatigue, dizziness, or mild diarrhea.

• Serious Concerns:

  • Can cause adrenal insufficiency, requiring hormone replacement therapy.

  • May affect liver function and blood counts.

  • Rarely, neurological symptoms such as confusion or ataxia may occur.

• Precautions:

  • Regular monitoring of hormone levels, liver function, and blood counts is essential.

  • Patients should follow the prescribed dose strictly to avoid adrenal crisis.

  • Inform the doctor about all other medications to prevent interactions.

• Storage: Store at room temperature, away from moisture, heat, and direct sunlight.