What is Aflibercept Injection?

Aflibercept Injection is a targeted biological medication used in the treatment of certain eye disorders and cancers. It belongs to a class of drugs known as vascular endothelial growth factor (VEGF) inhibitors, which work by blocking abnormal blood vessel growth.

It is widely used in ophthalmology for conditions such as age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). In oncology, Aflibercept is also used in combination therapy for certain types of cancers, including metastatic colorectal cancer.

Description

Aflibercept Injection is a sterile solution administered either intravitreally (into the eye) or intravenously depending on the indication. It works by binding to VEGF proteins, preventing them from promoting abnormal blood vessel formation and leakage.

Available in multiple strengths (2 mg/0.05 ml, 100 mg/4 ml, and 200 mg/8 ml), it allows precise dosing for both ophthalmic and oncological applications.

Uses of Aflibercept Injection

• Treatment of wet age-related macular degeneration (AMD)
• Management of diabetic macular edema (DME)
• Treatment of macular edema following retinal vein occlusion (RVO)
• Used in metastatic colorectal cancer (in combination with chemotherapy)
• Helps reduce abnormal blood vessel growth and fluid leakage

Indications

• Indicated for patients with retinal diseases affecting vision
• Used in cancer patients requiring anti-angiogenic therapy
• Administered only by trained healthcare professionals
• Dosage and route depend on the specific condition

Benefits

• Improves and stabilizes vision in retinal disorders
• Reduces swelling and fluid accumulation in the retina
• Inhibits tumor blood supply in cancer treatment
• Provides targeted action with proven clinical effectiveness
• Available in multiple strengths for flexible dosing

Drug Interactions

Aflibercept may interact with:

• Other anti-VEGF agents
• Chemotherapy drugs (when used in oncology)
• Corticosteroids
• Immunosuppressants

Always inform your doctor about all medications and treatments you are receiving.

How Aflibercept Works

• Binds to VEGF-A, VEGF-B, and placental growth factor (PlGF)
• Prevents formation of abnormal blood vessels
• Reduces leakage from existing vessels
• Helps restore normal tissue function and slows disease progression

Warnings & Precautions

• Must be administered by a qualified healthcare professional
• Risk of eye infection (endophthalmitis) with intravitreal use
• Monitor for increased intraocular pressure
• May increase risk of bleeding or clotting events in cancer patients
• Not recommended during pregnancy unless clearly necessary

General Instructions

• Do not self-administer
• Follow your doctor’s treatment schedule strictly
• Attend all follow-up appointments for monitoring
• Report any vision changes, eye pain, or redness immediately
• Maintain proper hygiene around the treatment area

Storage Information

• Store under refrigerated conditions (2°C to 8°C)
• Do not freeze
• Keep in original packaging to protect from light
• Keep out of reach of children and pets

Special Advice for Patients

• Avoid touching or rubbing the eyes after injection
• Monitor vision changes and report immediately
• Maintain regular eye examinations
• Follow your oncologist’s or ophthalmologist’s advice carefully

Why Choose Onco India International?

At Onco India International, we are committed to delivering high-quality, affordable, and globally trusted specialty medicines. Our Aflibercept Injection is manufactured under strict quality standards to ensure safety, precision, and effectiveness in both ophthalmic and oncology treatments.