Amitriptyline Hydrochloride (HCl) Tablets

Manufactured by Onco India International

Overview

Amitriptyline Hydrochloride is a tricyclic antidepressant (TCA) primarily used for the treatment of major depressive disorder (MDD). In addition to its antidepressant effects, it is widely prescribed for chronic pain management, certain anxiety disorders, and insomnia (off-label).

It works by balancing neurotransmitters in the brain, helping improve mood, reduce anxiety, and relieve certain types of pain.

Mechanism of Action

Amitriptyline inhibits the reuptake of serotonin and norepinephrine, increasing their levels in the brain’s synaptic cleft. This enhances mood regulation and emotional stability. Its anticholinergic properties also contribute to pain relief in conditions such as neuropathic pain and fibromyalgia.

Indications

• Major Depressive Disorder (MDD)

• Chronic pain syndromes (neuropathic pain, fibromyalgia)

• Anxiety disorders (off-label)

• Insomnia (off-label)

Dosage & Administration

• Form: Oral tablets (10 mg, 25 mg, 50 mg, 100 mg)

• Typical use: Taken once daily, usually in the evening due to sedative effects

• Directions: Swallow whole with water; do not crush or chew

• Dosage is individualized based on patient response, severity of symptoms, and tolerability

Possible Side Effects

Common:

• Drowsiness

• Dry mouth

• Constipation

• Weight gain

• Blurred vision

Serious (seek immediate medical attention):

• Severe mood changes or suicidal thoughts

• Heart rhythm disturbances

• Seizures

• Allergic reactions (rash, swelling, breathing difficulty)

Warnings & Precautions

• Mental health monitoring: Watch for worsening depression or unusual behavior changes

• Cardiac risks: May cause arrhythmias—use caution in patients with heart disease

• Alcohol & CNS depressants: Avoid, as they can enhance sedative effects

• Pregnancy & breastfeeding: Use only if potential benefits outweigh risks

• Do not discontinue suddenly; taper under medical supervision

Missed Dose

If a dose is missed, take it as soon as remembered unless it’s close to the next dose. Do not double doses.

Overdose Risks

Overdose can cause severe drowsiness, confusion, rapid heartbeat, seizures, or fainting. Emergency medical care is required immediately.

Self-Care Tips While on Amitriptyline

• Maintain a healthy diet and exercise routine to help manage weight gain

• Stay hydrated to reduce dry mouth

• Increase dietary fiber to prevent constipation

Market Insight

The global antidepressant market, including Amitriptyline HCl, continues to grow steadily due to rising awareness of mental health conditions and the increasing prevalence of chronic pain disorders. Amitriptyline remains a cost-effective and versatile treatment option in many healthcare settings.

Conclusion

Amitriptyline Hydrochloride Tablets by Onco India International offer a proven, effective solution for depression, chronic pain, and certain anxiety disorders. When used under proper medical guidance, patients can achieve significant symptom relief and improved quality of life.