Amlodipine and Ramipril Information

By Onco India International

Overview

Amlodipine and Ramipril are prescription medicines often used together to control high blood pressure and protect heart health. They work in different but complementary ways to relax blood vessels, improve blood flow, and reduce strain on the heart.

• Amlodipine – A calcium channel blocker that relaxes the smooth muscles in artery walls, widening the blood vessels and lowering blood pressure.

• Ramipril – An ACE inhibitor that blocks the production of angiotensin II, a chemical that narrows blood vessels. This also reduces the hormone aldosterone, decreasing salt and water retention.

When combined, they offer stronger blood pressure control than either drug alone, lowering the risk of heart attacks, strokes, and kidney problems linked to hypertension.

Uses

Doctors prescribe Amlodipine + Ramipril mainly for:

• Hypertension (High Blood Pressure) – Especially when one drug alone is insufficient.

• Stable Angina – To prevent chest pain caused by reduced heart blood flow.

• Post-Heart Attack Care – To reduce the chance of another attack.

• Heart Failure – To improve heart pumping efficiency.

• Kidney Protection in Diabetes – Slows the progression of kidney damage.

Indications

Recommended for adults with:

• Moderate to severe hypertension not controlled by single therapy.

• Persistent high blood pressure after using either a calcium channel blocker or ACE inhibitor alone.

• Increased heart strain or kidney problems needing combination therapy.

• Recovery after certain heart events, such as heart failure or heart attack.

How It Works

• Amlodipine widens arteries by relaxing the vessel wall muscles.

• Ramipril reduces vessel constriction by blocking angiotensin II formation and lowering fluid retention.

Together, they:

• Lower blood pressure.

• Reduce heart workload.

• Improve oxygen supply to body tissues.

Dosage Guidelines

• Usual starting dose: 5 mg Amlodipine + 2.5 mg Ramipril once daily.

• Maximum dose: 10 mg Amlodipine + 10 mg Ramipril once daily.

• Take at the same time each day, with or without food.

• Swallow whole with water. Do not chew or crush.

• If a dose is missed, take it as soon as possible unless it’s close to the next dose—never double up.

Drug Interactions

May interact with:

• Diuretics – May cause excessive BP drop or dehydration.

• Potassium supplements – Risk of high potassium levels.

• NSAIDs (e.g., ibuprofen) – Can reduce Ramipril’s effect.

• Lithium – Higher risk of toxicity.

• Simvastatin – Increased muscle injury risk.

• Other BP medicines – Possible dizziness or fainting.

Avoid combining with:

• Aliskiren (in diabetics) – Risk of kidney damage/high potassium.

• Sacubitril/valsartan – Risk of dangerous swelling.

• Strong CYP3A4 inhibitors (e.g., ketoconazole) – Slows Amlodipine breakdown.

• Grapefruit products – Increase Amlodipine blood levels.

• Excess alcohol – May drop BP too much.

Benefits

• Effective BP reduction in hypertension.

• Reduces heart strain.

• Prevents stable angina-related chest pain.

• Lowers risk of stroke and heart failure.

• Protects kidney function in diabetes.

• Convenient once-daily dosing.

Side Effects

Common:

• Swelling of feet/ankles

• Dizziness, headache

• Flushing of face/neck

• Dry cough

• Fatigue

Less Common:

• Rash, itching

• Taste changes

• Muscle cramps

• Nausea

• Low white blood cells

Rare but serious:

• Angioedema (swelling of face/throat)

• Severe drop in BP

• Liver issues (jaundice)

Seek immediate medical attention for any unusual symptoms.

When Not to Use

Avoid if you have:

• Allergy to Amlodipine, Ramipril, or similar drugs.

• History of ACE inhibitor-induced swelling.

• Low resting BP.

• Pregnancy (especially after 1st trimester).

• Breastfeeding (unless approved by a doctor).

• Severe kidney artery blockages.

Safety Advice

• Avoid driving if dizzy or tired.

• Limit alcohol intake.

• Tell your doctor before surgery or dental work.

• Regularly monitor BP, kidney function, and potassium.

• Never stop medication without medical advice.

Lifestyle & Dietary Tips

• Reduce salt intake to <5 g/day.

• Avoid processed snacks, pickles, and salty foods.

• Eat fresh vegetables, fruits, and lean proteins.

• Exercise daily (e.g., 30-min walk).

• Sleep 7–8 hours/night.

• Avoid smoking and limit alcohol.

Storage

• Store at 15°C–25°C in original packaging.

• Keep away from moisture, light, and heat.

• Do not freeze.

• Keep out of reach of children and pets.

• Dispose of unused medicine safely.

Onco India International supplies high-quality Amlodipine + Ramipril tablets, manufactured to international standards for safety and efficacy. Consult your healthcare provider for proper dosage and monitoring when using this medication.