Amlodipine and Valsartan Tablets – Onco India International

Overview

Amlodipine and Valsartan are trusted medications for lowering high blood pressure (hypertension). They are combined in a single tablet to simplify treatment and enhance patient compliance.

• Amlodipine belongs to the class of medicines known as calcium channel blockers (CCBs). It relaxes the heart and blood vessels, improving blood flow.

• Valsartan is an angiotensin II receptor blocker (ARB). It prevents the action of angiotensin II—a natural chemical that narrows blood vessels—thereby helping them relax and widen.

By targeting high blood pressure through two different mechanisms, this combination improves blood pressure control and reduces the risk of heart attack, stroke, and kidney problems.

Uses

• Management of essential hypertension (high blood pressure without a known cause).

• Treatment for patients requiring combination therapy when single-drug treatment is insufficient.

• Reduction of risks associated with uncontrolled hypertension, such as:

  • Myocardial infarction (heart attack)

  • Cerebrovascular accident (stroke)

  • Heart failure

  • Renal failure

Indications

• Inadequate blood pressure control with Amlodipine or Valsartan alone.

• Patients needing multiple drugs to reach target blood pressure.

• Patients unable to tolerate high doses of a single drug due to side effects.

Benefits

• Greater effectiveness compared to monotherapy.

• Reduced risk of dose-related side effects (e.g., less swelling from Amlodipine).

• Convenient single-tablet formulation for improved adherence.

• Protects heart, brain, and kidneys through better blood pressure control.

How It Works

Amlodipine (Calcium Channel Blocker)

• Prevents calcium from entering smooth muscle cells in the heart and blood vessels.

• Relaxes blood vessels, lowers resistance, and makes it easier for the heart to pump blood.

Valsartan (Angiotensin II Receptor Blocker)

• Blocks the effects of angiotensin II, preventing blood vessel narrowing.

• Keeps blood vessels relaxed and open, lowering blood pressure and easing strain on the heart.

Dosage Guidelines

Directions for Use:

• Take orally once daily, with or without food.

• Take at the same time each day to maintain consistent blood levels.

• Swallow whole with water; do not crush or chew.

Typical Dosage:

• 5 mg Amlodipine + 160 mg Valsartan once daily.

• Adjusted between 5/160 mg and 10/320 mg depending on response.

• Dose changes typically made after 1–2 weeks based on blood pressure readings.

When Not to Use

• Pregnancy (especially after the first trimester) – may harm the fetus.

• Severe liver or kidney problems.

• Known allergy to Amlodipine, Valsartan, or similar drugs.

• History of angioedema with ARBs or ACE inhibitors.

• Bilateral renal artery stenosis.

Drug Interactions

May Be Used With:

• Diuretics (e.g., thiazides)

• Beta-blockers (under medical supervision)

• Statins (with caution)

Avoid or Use With Caution:

• NSAIDs (e.g., ibuprofen, naproxen) – may reduce effectiveness and harm kidneys.

• Potassium supplements or potassium-sparing diuretics – risk of high potassium levels.

• Lithium – increased risk of toxicity.

• Simvastatin – limit to 20 mg daily when used with Amlodipine.

• Rifampin or St. John’s Wort – may reduce Valsartan levels.

• CYP3A4 inhibitors (e.g., ketoconazole) – may increase Amlodipine levels.

Safety Advice

Concerns:

• Orthostatic hypotension (drop in blood pressure when standing).

• Peripheral edema (swelling).

• Hyperkalemia (high potassium), especially in kidney impairment.

• Possible dizziness and fatigue when starting treatment.

Precautions:

• Use with caution in elderly patients, those with heart failure, or aortic stenosis.

• Stop immediately if pregnancy occurs.

• Avoid breastfeeding unless medically necessary.

Lifestyle Recommendations

• Exercise at least 30 minutes most days.

• Reduce salt intake (1,500–2,300 mg/day).

• Eat a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins.

• Limit alcohol and avoid smoking.

• Manage stress through relaxation techniques such as yoga or meditation.

Storage Instructions

• Store between 15°C and 30°C.

• Keep away from sunlight, moisture, and heat.

• Store in the original packaging.

• Keep out of reach of children and pets.

• Do not use after the expiration date.

Manufactured & Marketed by:
Onco India International
Your trusted partner in advanced pharmaceutical solutions.