Ceftriaxone + Tazobactam Injection

• Type: Combination antibiotic injection

• Drug Class:

  • Ceftriaxone: Third-generation cephalosporin antibiotic

  • Tazobactam: Beta-lactamase inhibitor

• Form: Injectable powder or solution, given intravenously (IV) or intramuscularly (IM)

How It Works

• Ceftriaxone kills bacteria by blocking cell wall synthesis, causing bacterial cell death.

• Tazobactam inhibits beta-lactamase enzymes, which are produced by some bacteria to resist antibiotics.

• Together, this combination offers broader coverage, especially against beta-lactamase–producing bacteria.

Common Uses

This combination is used for moderate to severe bacterial infections, such as:

• Respiratory tract infections (pneumonia, bronchitis)

• Sepsis (bloodstream infections)

• Urinary tract infections (complicated UTIs)

• Intra-abdominal infections (peritonitis, abscesses)

• Skin and soft tissue infections

• Biliary tract infections

• Bone and joint infections

• Pelvic inflammatory disease and gynecological infections

Advantages

• Broader coverage than ceftriaxone alone

• Useful against many drug-resistant gram-negative bacteria

• Once- or twice-daily dosing in many cases, making it convenient for hospital use

• Good penetration into tissues, including bile ducts — very effective in biliary tract infections

Possible Side Effects

• Pain, swelling, or irritation at injection site

• Diarrhea, nausea, or vomiting

• Mild rash or allergic reaction

• Headache or fever

• Changes in liver enzymes or kidney function (seen in blood tests)

• Rare: severe allergic reaction (anaphylaxis), gallbladder sludge or stones with prolonged use

Precautions

• Kidney and liver function monitoring may be needed in long-term use

• Use with caution in patients allergic to penicillins or cephalosporins

• Overuse may promote antibiotic resistance

• Should be administered under medical supervision