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Clozapine Tablets

Product/Composition Clozapine Tablets
Strength 25,50, 100mg
Form Tablets
Production Capacity 10 Million Tablet/Month
Packaging 10 X 10 Tablets / Box
Therapeutic use Anti Anxiety, Anti Depressant, Anti Psychotic, Anxiolytics
Package Insert/Leaflet Available upon request

INQUIRE ABOUT Clozapine Tablets

Clozapine Tablets

Category: Atypical antipsychotic
Form: Oral tablets

Uses:

  • Treatment of resistant schizophrenia in patients who do not respond to other antipsychotics.

  • Management of schizophrenia with high risk of suicidal behavior.

  • Sometimes used in severe psychotic disorders under strict medical supervision.

Mechanism of Action:

  • Clozapine blocks dopamine (D2) and serotonin (5-HT2A) receptors in the brain.

  • Reduces psychotic symptoms such as hallucinations, delusions, and thought disorders.

  • Has a lower risk of extrapyramidal symptoms compared to typical antipsychotics due to selective receptor activity.

Administration:

  • Taken orally, usually once or twice daily, depending on condition and tolerance.

  • Dose is gradually increased to minimize side effects.

  • Regular monitoring of blood counts is mandatory due to risk of agranulocytosis.

Side Effects:

  • Common: sedation, drowsiness, weight gain, drooling, constipation.

  • Other: dizziness, tachycardia, low blood pressure, blurred vision.

  • Serious but rare:

    • Agranulocytosis (severely low white blood cells)

    • Myocarditis (heart inflammation)

    • Seizures

    • Severe metabolic disturbances (diabetes, high cholesterol)

Precautions:

  • Mandatory regular blood monitoring to detect agranulocytosis.

  • Avoid abrupt discontinuation to prevent withdrawal symptoms or relapse.

  • Use cautiously in elderly patients, those with cardiovascular disease, or seizure history.

  • Avoid alcohol and other CNS depressants.

  • Not recommended during pregnancy or breastfeeding unless prescribed with caution.

Summary:
Clozapine Tablets are an atypical antipsychotic used mainly for treatment-resistant schizophrenia and patients at high risk of suicide. They work by blocking dopamine and serotonin receptors, reducing psychotic symptoms while minimizing movement-related side effects. Common side effects include sedation, weight gain, and constipation, while serious risks like agranulocytosis, myocarditis, and seizures require strict medical supervision and regular blood monitoring.