Deferasirox Tablets are a medicine used as an iron chelator, which means they help remove excess iron from the body.

Here are the key details:

• Composition: Each tablet contains Deferasirox as the active ingredient, available in different strengths such as 90 mg, 180 mg, and 360 mg.

• Dosage Form: Oral tablets, often available as film-coated tablets or dispersible tablets.

• Mode of Action: Deferasirox binds to excess iron in the blood (especially iron that accumulates after frequent blood transfusions) and forms a complex that is excreted mainly through the stool. This reduces harmful iron overload in vital organs.

• Uses:

  • Treatment of chronic iron overload in patients receiving regular blood transfusions (such as those with thalassemia major, sickle cell anemia, or other chronic anemias).

  • Sometimes used in patients with non-transfusion-dependent thalassemia who develop iron overload.

• Treatment Goal: To prevent long-term organ damage (like to the liver, heart, and endocrine system) caused by excess iron accumulation.

• Side Effects:

  • Common: nausea, vomiting, abdominal pain, constipation, diarrhea, rash.

  • Serious: kidney problems, liver problems, hearing or vision disturbances, gastrointestinal bleeding.

• Precautions:

  • Requires regular monitoring of kidney and liver function.

  • Blood iron levels (serum ferritin) should be checked regularly to adjust dosage.

  • Not recommended in patients with severe kidney or liver impairment.

  • Caution with other medicines that affect kidney or liver.

  • Not generally advised during pregnancy unless clearly needed.