Disulfiram Tablets are a medicine used primarily to support the treatment of chronic alcohol dependence by discouraging alcohol consumption.

Here are the key details:

• Composition: Each tablet contains Disulfiram as the active ingredient, commonly available in strengths like 250 mg.

• Dosage Form: Oral tablets, usually taken once daily.

• Mode of Action: Disulfiram works by blocking the enzyme aldehyde dehydrogenase, which is responsible for metabolizing alcohol in the body. When a person consumes alcohol while taking Disulfiram:

  • Acetaldehyde (a toxic byproduct of alcohol metabolism) accumulates.

  • This causes unpleasant reactions, such as flushing, nausea, vomiting, headache, and palpitations.

  • The reaction discourages further alcohol consumption.

• Uses:

  • Adjunct therapy in chronic alcoholism, to maintain abstinence from alcohol.

  • Used as part of a comprehensive treatment plan including counseling, behavioral therapy, and support groups.

• Treatment Goal: To help individuals avoid alcohol consumption by producing a strong deterrent effect and supporting long-term sobriety.

• Side Effects:

  • Common: drowsiness, fatigue, headache, metallic or garlic-like taste in the mouth, skin rash.

  • Serious: liver toxicity (hepatitis), neuropathy, severe allergic reactions.

  • Reactions to alcohol while on Disulfiram can be severe and potentially dangerous (e.g., hypotension, heart palpitations).

• Precautions:

  • Must avoid all forms of alcohol (including cough syrups, sauces, or mouthwashes containing alcohol).

  • Liver function should be monitored before and during treatment.

  • Not recommended for patients with severe heart disease, psychosis, or liver disease.

  • Treatment should only be started under medical supervision.

👉 Disulfiram is not a cure for alcoholism but works as a behavioral aid to help maintain abstinence when combined with counseling and support.