Drotaverine and Mefenamic Acid Tablets are a combination medicine used to relieve pain and smooth muscle spasms, particularly in the abdomen.

Here are the key details:

• Composition: Each tablet contains:

  • Drotaverine – an antispasmodic that relaxes smooth muscles.

  • Mefenamic Acid – a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation.

• Dosage Form: Oral tablets, usually taken as needed or prescribed by a doctor.

• Mode of Action:

  • Drotaverine: Inhibits phosphodiesterase enzymes in smooth muscle, leading to relaxation and relief of spasms.

  • Mefenamic Acid: Blocks cyclo-oxygenase (COX) enzymes, reducing the production of prostaglandins, which decreases pain, inflammation, and menstrual cramps.

• Uses:

  • Relief of abdominal pain and cramps caused by conditions such as dysmenorrhea (menstrual pain), gastrointestinal colic, or urinary tract spasms.

  • Management of muscle spasms associated with smooth muscles.

• Treatment Goal: To reduce pain and relax muscles, providing faster relief from cramps or spasmodic discomfort.

• Side Effects:

  • Common: nausea, vomiting, dizziness, headache, mild stomach upset.

  • Less common/serious: allergic reactions, gastrointestinal bleeding or ulcers (from mefenamic acid), low blood pressure or rapid heartbeat (rare with drotaverine).

• Precautions:

  • Avoid in patients with peptic ulcer, severe kidney or liver disease, or known NSAID allergy.

  • Use caution in patients with heart problems or low blood pressure.

  • Should be taken with food or water to reduce stomach irritation.

  • Not recommended during late pregnancy or breastfeeding unless prescribed.

👉 This combination is particularly effective for menstrual cramps, abdominal colic, and other spasmodic pains, as it addresses both muscle spasm and inflammation-related pain.