Esomeprazole and Domperidone Capsules – Onco India International

What are Esomeprazole and Domperidone Capsules?

Esomeprazole and Domperidone Capsules are a combination medicine widely used for managing various stomach and digestion-related problems such as heartburn, acid reflux, bloating, post-meal fullness, indigestion, and nausea.

This capsule combines two active ingredients:

• Esomeprazole – reduces excess acid production in the stomach by blocking acid-producing pumps.

• Domperidone – improves stomach and intestinal movement, allowing food to pass smoothly through the digestive tract, and prevents nausea and vomiting.

Together, they provide relief from acid reflux, improve digestion, and reduce discomfort caused by slow gastric emptying.

Description

• Esomeprazole works by suppressing stomach acid secretion, which helps heal ulcers, reduces stomach pain, and relieves heartburn.

• Domperidone acts as a dopamine antagonist, improving gut motility and blocking nausea signals from the brain’s vomiting center.

Each capsule generally contains Esomeprazole 40 mg (enteric-coated) and Domperidone 30 mg (extended-release).

Uses / Indications

This combination capsule is prescribed for:

• Gastroesophageal reflux disease (GERD)

• Heartburn & acidity

• Indigestion / dyspepsia

• Nausea and vomiting

• Bloating and post-meal fullness

• NSAID-induced ulcer prevention

Benefits

• Provides dual action: reduces acid + improves motility.

• Relieves heartburn, acidity, and digestive discomfort.

• Prevents nausea and vomiting.

• Protects the stomach lining from acid-related damage.

• Improves food passage, digestion, and overall comfort.

Side Effects

Common side effects:

• Headache

• Dizziness

• Dry mouth

• Stomach cramps

• Constipation or loose stools

• Flatulence

Less common but serious side effects:

• Irregular heartbeat

• Rash or swelling

• Muscle weakness or cramps

• Excessive dizziness or fainting

• Breast enlargement or discharge (rare, due to Domperidone)

• Low magnesium or vitamin B12 levels with long-term Esomeprazole use

• Jaundice (possible liver issue)

How It Works

• Esomeprazole blocks stomach acid pumps → reduces acidity & heals acid-related damage.

• Domperidone enhances stomach muscle movement → prevents delayed digestion, nausea, and vomiting.

Together, they provide complete relief from acid reflux and gastric motility issues.

Dosage Guidelines

• Take once daily, preferably in the morning before meals.

• Swallow the capsule whole with water (do not chew or crush).

• Dosage depends on medical condition and doctor’s instructions.

• If a dose is missed, take it when remembered. Skip if close to next dose.

• Do not stop treatment suddenly without medical advice.

When Not to Use

Avoid this capsule if you have:

• Allergy to Esomeprazole or Domperidone

• Severe liver disease

• Heart rhythm disorders

• Pituitary gland tumors (prolactinoma)

• Interactions with specific medications (like certain antifungals, antibiotics, or seizure medicines)

Drug Interactions

May interact with:

• Antifungals: ketoconazole, itraconazole

• Antibiotics: erythromycin, clarithromycin

• HIV drugs: atazanavir

• Seizure drugs: phenytoin

• Blood thinners: warfarin

• High-dose methotrexate

• Diuretics (especially in elderly or kidney patients)

Safety Advice

• Use during pregnancy or lactation only on doctor’s advice.

• Avoid alcohol as it worsens acidity.

• Do not drive or operate machinery if feeling dizzy.

• Patients with liver/kidney issues should take only under strict medical supervision.

General Instructions

• Follow dosage strictly as prescribed.

• Do not stop medication suddenly.

• Regular check-ups may be needed if used long term.

• Avoid lying down immediately after meals.

Lifestyle & Dietary Tips

• Eat smaller, frequent meals instead of overeating.

• Avoid spicy, oily, and fried foods.

• Reduce tea, coffee, chocolate, and alcohol intake.

• Stay upright for at least 30 minutes after meals.

• Quit smoking and maintain a healthy weight.

• Elevate the head of your bed if suffering from night-time reflux.

Comparison with Other Treatments

• More effective than antacids (which only neutralize acid temporarily).

• Stronger than H2 blockers like ranitidine.

• Works better than single-drug therapies when both acid reflux + delayed digestion are issues.

• Not for quick relief of sudden acidity – antacids may still be needed for immediate relief.

Precautions & Warnings

• Long-term use may cause low magnesium or vitamin B12.

• Domperidone may raise prolactin levels (rare breast changes/discharge).

• Do not stop treatment without consulting your doctor.

• Regular monitoring may be required for liver function and minerals.

Storage

• Store below 25°C, in a cool, dry place.

• Protect from direct sunlight and moisture.

• Keep out of children’s reach.

• Do not refrigerate or freeze.

• Always check expiry date before use.

Manufactured & Marketed by

Onco India International
A trusted name in providing high-quality pharmaceutical solutions for gastric and digestive health.