Everolimus is a medicine that belongs to a class of drugs called mTOR inhibitors. It is used to manage certain cancers, abnormal cell growth conditions, and in some cases, to prevent organ transplant rejection.

Here are the key details:

• Composition: The active ingredient is Everolimus, available in oral tablet form, commonly in strengths such as 2.5 mg, 5 mg, and 10 mg.

• Dosage Form: Oral tablets, usually taken once daily at the same time each day, as prescribed by a doctor.

• Mode of Action:

  • Everolimus blocks the mTOR (mammalian target of rapamycin) pathway, which is crucial for cell growth, proliferation, and survival.

  • By inhibiting this pathway, it slows the growth of cancer cells or abnormal tissues and suppresses immune responses when needed.

• Uses:

  • Cancers – such as advanced kidney cancer, certain breast cancers, neuroendocrine tumors, and some brain tumors.

  • Tuberous sclerosis complex – to reduce benign tumors in organs.

  • Organ transplant – to prevent rejection by suppressing the immune system under careful medical supervision.

• Treatment Goal: To slow or stop abnormal cell growth, reduce tumor size, prevent organ rejection, and improve quality of life depending on the condition.

• Side Effects:

  • Common: mouth ulcers, fatigue, diarrhea, nausea, rash, and increased risk of infections.

  • Less common/serious: liver or kidney problems, high blood sugar or cholesterol, lung inflammation, and severe infections.

• Precautions:

  • Regular monitoring of blood counts, liver and kidney function, and lipid levels is required.

  • Avoid live vaccines during treatment.

  • Not recommended during pregnancy or breastfeeding.

  • Can interact with other medications affecting liver enzymes.

  • Tablets should be swallowed whole unless otherwise instructed.

👉 Everolimus is a targeted therapy that focuses on specific pathways in the body to control abnormal cell growth, requiring careful supervision to balance effectiveness and side effects.