Fludarabine Phosphate Tablets are a medicine used in the treatment of certain types of blood cancers. They belong to a class of drugs called antimetabolites, which interfere with the growth and replication of cancer cells.

Here are the key details:

• Composition: Each tablet contains Fludarabine phosphate as the active ingredient, commonly in strengths like 10 mg or 50 mg.

• Dosage Form: Oral tablets, usually taken once daily, as prescribed by a doctor, often for a set cycle of days.

• Mode of Action:

  • Fludarabine is a purine analog, which mimics the building blocks of DNA.

  • It gets incorporated into the DNA of rapidly dividing cells, inhibiting DNA synthesis and leading to cell death, particularly in cancerous white blood cells.

• Uses:

  • Chronic lymphocytic leukemia (CLL) – primarily in patients with relapsed or resistant disease.

  • Sometimes used in combination with other chemotherapy drugs for other blood cancers or lymphomas under medical supervision.

• Treatment Goal: To slow or stop cancer cell growth, reduce tumor burden, and improve survival in patients with blood cancers.

• Side Effects:

  • Common: fatigue, nausea, vomiting, diarrhea, loss of appetite, fever, low blood counts (anemia, leukopenia, thrombocytopenia).

  • Less common/serious: infections due to weakened immunity, neurological effects (confusion, weakness), liver or kidney issues, allergic reactions.

• Precautions:

  • Regular monitoring of blood counts, liver and kidney function is essential.

  • Avoid infections due to immunosuppression.

  • Not recommended during pregnancy or breastfeeding.

  • Dose adjustments may be needed for patients with kidney impairment.

  • Should be taken exactly as prescribed; missing doses or altering the schedule can affect effectiveness.

👉 Fludarabine phosphate is effective for targeting rapidly dividing cancerous white blood cells, making it a key therapy in certain leukemia and lymphoma treatment regimens.