Granisetron HCl Tablets are a medicine used to prevent nausea and vomiting, particularly those caused by chemotherapy, radiation therapy, or surgery. They belong to a class of drugs called 5-HT3 receptor antagonists.

Here are the key details:

• Composition: Each tablet contains Granisetron hydrochloride, commonly in strengths such as 1 mg or 2 mg.

• Dosage Form: Oral tablets, usually taken once or twice daily, as prescribed by a doctor.

• Mode of Action:

  • Granisetron blocks serotonin (5-HT3) receptors in the brain and gastrointestinal tract.

  • This prevents the activation of the vomiting reflex, reducing nausea and vomiting.

• Uses:

  • Chemotherapy-induced nausea and vomiting (CINV).

  • Radiation-induced nausea and vomiting (RINV).

  • Postoperative nausea and vomiting (PONV) after surgery.

• Treatment Goal: To prevent or control nausea and vomiting, improving patient comfort and adherence to treatment.

• Side Effects:

  • Common: headache, constipation, dizziness, fatigue.

  • Less common/serious: allergic reactions, irregular heartbeat, severe dizziness, low blood pressure.

• Precautions:

  • Use caution in patients with heart rhythm disorders.

  • Inform the doctor about other medications, especially those affecting heart rhythm.

  • Not recommended during pregnancy or breastfeeding unless prescribed.

  • Adequate hydration and monitoring may be advised during chemotherapy or post-surgery.

👉 Granisetron HCl is effective for preventing nausea and vomiting by blocking serotonin signals that trigger the vomiting reflex, making it widely used in oncology and surgical settings.