Ketoprofen Lyophilized Injection is a parenteral dosage form of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID). It is usually prepared as a lyophilized (freeze-dried) powder that requires reconstitution with a suitable diluent before administration.

Here are the key details:

1. Composition and Form:

• Contains ketoprofen, an NSAID from the propionic acid derivative group.

• Supplied as a sterile lyophilized powder in vials.

• Reconstituted with sterile water or other approved solvent before intravenous (IV) or intramuscular (IM) injection.

2. Mechanism of Action:

• Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced prostaglandin synthesis.

• Provides analgesic, anti-inflammatory, and antipyretic effects.

3. Indications:

• Acute pain management (postoperative, musculoskeletal, trauma-related).

• Inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis.

• Short-term relief of moderate to severe pain where oral administration is not possible.

4. Administration:

• Usually given intramuscularly or intravenously after reconstitution.

• Dose and frequency depend on severity of pain, patient’s condition, and physician’s guidance.

5. Side Effects:

• Gastrointestinal irritation, nausea, vomiting, abdominal pain.

• Risk of peptic ulcer, GI bleeding, or perforation with prolonged use.

• Dizziness, headache, somnolence.

• Renal function impairment in susceptible patients.

• Rare hypersensitivity or anaphylactoid reactions.

6. Contraindications:

• History of hypersensitivity to ketoprofen or other NSAIDs.

• Active gastrointestinal ulceration or bleeding.

• Severe renal, hepatic, or heart failure.

• History of aspirin/NSAID-induced asthma or allergy.

7. Precautions:

• Use cautiously in elderly patients and those with cardiovascular risk.

• Monitor renal and liver function during therapy.

• Avoid prolonged use in parenteral form; switch to oral formulations when possible.

8. Storage:

• Store vials in a cool, dry place, protected from light.

• Reconstituted solution should be used promptly or within the recommended stability period.