Lamivudine, Zidovudine, and Nevirapine Tablets are a combination antiviral medicine used to manage HIV infection. This combination brings together three drugs that work in different ways to control the virus and support the immune system.

Here are the key details:

• Composition:

  • Lamivudine – a nucleoside reverse transcriptase inhibitor (NRTI) that prevents the virus from multiplying.

  • Zidovudine – another NRTI that interferes with HIV replication by targeting the reverse transcriptase enzyme.

  • Nevirapine – a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks the enzyme the virus needs to replicate.

• Main Use: Prescribed for managing HIV infection. This combination helps reduce viral load, improve immune function, and slow progression of the disease. It is also sometimes used to prevent mother-to-child transmission of HIV.

• How It Works:

  • Lamivudine and Zidovudine inhibit the reverse transcriptase enzyme to stop viral replication.

  • Nevirapine binds to the reverse transcriptase enzyme differently, providing a complementary action.
    Together, they prevent the virus from multiplying and allow the immune system to recover.

• Administration: Taken orally, usually twice daily, as directed by the doctor. It is important to take doses at the same times each day and not to skip doses.

• Common Side Effects: Nausea, vomiting, diarrhea, headache, fatigue, dizziness, mild skin rash, or insomnia.

• Serious Concerns: Rarely, it may cause liver problems, severe skin reactions, lactic acidosis (buildup of lactic acid), bone marrow suppression, or worsening of infections.

• Precautions:

  • Requires regular monitoring of liver function, kidney function, and blood counts.

  • Do not stop taking the medication suddenly to prevent viral resistance.

  • Inform the doctor of all other medications or supplements being taken, as interactions are possible.

• Storage: Store at room temperature, away from moisture, heat, and direct sunlight.