Linezolid I.V. Injection is an antibiotic belonging to the oxazolidinone class, used for treating serious bacterial infections caused by Gram-positive organisms, including strains resistant to other antibiotics.

Here are the key details:

---

1. Composition and Form:

• Active ingredient: Linezolid.

• Supplied as a sterile solution for intravenous (IV) administration.

• Typically available in concentrations suitable for direct IV infusion or further dilution.

2. Mechanism of Action:

• Inhibits bacterial protein synthesis by binding to the 23S portion of the 50S ribosomal subunit.

• Blocks the formation of the initiation complex for protein translation.

• Primarily bacteriostatic against most Gram-positive organisms but may be bactericidal against some strains of Streptococcus.

3. Antimicrobial Spectrum:

• Active against Gram-positive cocci, including:

  • Methicillin-resistant Staphylococcus aureus (MRSA)

  • Vancomycin-resistant Enterococcus (VRE)

  • Streptococcus pneumoniae (including penicillin-resistant strains)

• Not effective against most Gram-negative bacteria.

4. Indications:

• Complicated and uncomplicated skin and soft tissue infections caused by susceptible organisms.

• Nosocomial or community-acquired pneumonia due to Gram-positive bacteria.

• Infections due to VRE or MRSA where alternative therapy is inadequate.

• Used under strict medical supervision for severe, resistant infections.

5. Administration:

• Given by slow IV infusion, usually over 30–120 minutes.

• Dose typically weight-based (often 600 mg every 12 hours in adults), but may vary depending on renal or hepatic status.

• Duration depends on infection type, severity, and clinical response.

6. Side Effects:

• Hematologic: thrombocytopenia, anemia, leukopenia (especially with prolonged therapy).

• Gastrointestinal: nausea, vomiting, diarrhea, headache.

• Neurologic: peripheral neuropathy or optic neuropathy with extended use.

• Lactic acidosis: rare but serious.

• Hypersensitivity reactions: rash, pruritus, rare anaphylaxis.

7. Contraindications:

• Known hypersensitivity to linezolid or other oxazolidinones.

• Concomitant use of certain monoamine oxidase inhibitors (MAOIs) unless carefully managed (risk of serotonin syndrome).

8. Precautions:

• Monitor complete blood counts, especially if therapy >2 weeks.

• Use cautiously in patients with renal or hepatic impairment.

• Avoid prolonged use to reduce risk of neuropathy and myelosuppression.

• Check for drug interactions (e.g., serotonergic drugs, sympathomimetics).

9. Storage:

• Store at controlled room temperature, protected from light.

• Use aseptically and discard unused solution as per recommended guidelines.