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Mechlorethamine Injection

Product/Composition Mechlorethamine Injection
Strength 10mg
Form Injection
Production Capacity 1 Million Injection/Month
Therapeutic use Anti Cancer
Package Insert/Leaflet Available upon request

INQUIRE ABOUT Mechlorethamine Injection

Mechlorethamine Injection is a cytotoxic chemotherapy agent belonging to the alkylating agent class (nitrogen mustard group). It is used in the treatment of certain cancers and acts by interfering with DNA replication and cell division.

Here are the key details:

1. Composition and Form

  • Active ingredient: Mechlorethamine hydrochloride.

  • Supplied as a sterile lyophilized powder for reconstitution.

  • Intended for intravenous (IV) administration; some formulations also allow subcutaneous (SC) or topical use for localized therapy.

2. Mechanism of Action

  • Alkylates DNA by forming cross-links between DNA strands, which prevents DNA replication and transcription.

  • Leads to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells.

  • Non-specific to cell cycle phase but more effective on rapidly proliferating cells.

3. Indications

  • Hodgkin’s lymphoma (component of MOPP regimen: Mechlorethamine, Oncovin/vincristine, Procarbazine, Prednisone).

  • Certain non-Hodgkin’s lymphomas and other hematologic malignancies.

  • Occasionally used in palliative settings for resistant or advanced cancers.

4. Administration

  • Administered intravenously after reconstitution with sterile water or appropriate diluent.

  • Often given as part of combination chemotherapy regimens.

  • Requires careful handling due to high vesicant properties (can cause tissue necrosis if extravasated).

  • Dose is based on body surface area and treatment protocol.

5. Side Effects

Common:

  • Myelosuppression: leukopenia, thrombocytopenia, anemia.

  • Nausea, vomiting, mucositis.

Serious / less common:

  • Extravasation injury: severe tissue necrosis at injection site.

  • Secondary malignancies with long-term use.

  • Increased risk of infection due to immunosuppression.

  • Alopecia (hair loss).

  • Sterility (especially with repeated or high-dose therapy).

6. Contraindications

  • Hypersensitivity to mechlorethamine or related nitrogen mustards.

  • Severely suppressed bone marrow or active infections.

  • Pregnancy (highly teratogenic) and breastfeeding.

7. Precautions

  • Administer under strict hospital supervision with protective measures for staff due to its cytotoxic nature.

  • Monitor blood counts, renal and liver function regularly.

  • Ensure proper IV access to avoid extravasation.

  • Use antiemetics prophylactically to reduce nausea/vomiting.

8. Storage

  • Store lyophilized powder in a cool, dry place, protected from light.

  • Reconstituted solution should be used immediately or within the recommended timeframe due to instability.