Metformin HCl and Glimepiride Tablets are a combination medicine used to manage type 2 diabetes mellitus when blood sugar levels are not adequately controlled by diet, exercise, and single-drug therapy.

Here are the key details:

• Composition:

  • Metformin HCl – improves the body’s sensitivity to insulin and reduces glucose production in the liver.

  • Glimepiride – stimulates the pancreas to produce more insulin, helping lower blood sugar levels.

• Main Use:

  • Helps control high blood sugar in type 2 diabetes.

  • Reduces the risk of diabetes-related complications such as heart disease, kidney problems, and nerve damage.

• How It Works:

  • Metformin lowers glucose production in the liver and improves insulin sensitivity in muscles.

  • Glimepiride increases insulin secretion from the pancreas to lower blood sugar after meals.

• Administration: Taken orally, usually once daily with breakfast or as directed by the doctor. Tablets should be swallowed with water and taken consistently at the same time each day.

• Common Side Effects: Nausea, mild stomach upset, diarrhea, dizziness, or mild headache.

• Serious Concerns:

  • Risk of low blood sugar (hypoglycemia), especially if meals are skipped or combined with other diabetes medications.

  • Rarely, may cause lactic acidosis (mainly due to metformin), which is a medical emergency.

  • Allergic reactions or liver/kidney problems in susceptible patients.

• Precautions:

  • Monitor blood sugar regularly as advised by the doctor.

  • Avoid alcohol, as it may increase the risk of low blood sugar or lactic acidosis.

  • Inform the doctor about all other medications to prevent interactions.

• Storage: Store at room temperature, away from moisture, heat, and direct sunlight.