Methotrexate Tablets are a prescription medicine that belongs to the class of antimetabolite and immunosuppressive drugs. They are used to treat certain cancers and autoimmune diseases.

Here are the key details:

• Main Use:

  • Treats cancers such as leukemia, lymphoma, breast cancer, and other malignancies.

  • Manages autoimmune conditions like rheumatoid arthritis, psoriasis, and severe inflammatory disorders.

• How It Works: Methotrexate inhibits the enzyme dihydrofolate reductase, interfering with DNA and RNA synthesis in rapidly dividing cells. This action slows down the growth of cancer cells and suppresses overactive immune responses.

• Administration: Taken orally, usually once weekly or as prescribed by the doctor. The dose and schedule depend on the condition being treated. Consistency and strict adherence to the prescribed schedule are very important.

• Common Side Effects: Nausea, vomiting, mouth sores, mild hair thinning, fatigue, or mild liver enzyme changes.

• Serious Concerns:

  • Bone marrow suppression, increasing the risk of infections, anemia, or bleeding.

  • Liver toxicity or liver damage with long-term use.

  • Lung problems (pulmonary toxicity) or severe allergic reactions in rare cases.

• Precautions:

  • Regular monitoring of blood counts, liver, and kidney function is required.

  • Avoid alcohol, as it increases the risk of liver damage.

  • Inform the doctor about all other medications to prevent interactions.

  • Patients should avoid pregnancy while taking methotrexate due to risk of birth defects.

• Storage: Store at room temperature, away from moisture, heat, and direct sunlight.