Nevirapine Tablets are an antiretroviral medicine used in the management of HIV (Human Immunodeficiency Virus) infection. They belong to the class called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Here are the key details:

• Main Use:

  • Prescribed as part of combination antiretroviral therapy (ART) for HIV-1 infection.

  • Helps lower the viral load and increase CD4 cell counts, improving immune function.

  • Reduces the risk of HIV-related complications and transmission.

• How It Works:

  • Nevirapine blocks the action of the reverse transcriptase enzyme, which HIV needs to multiply.

  • This prevents the virus from making new copies of itself.

• Administration:

  • Taken orally, usually once or twice daily depending on the treatment phase and doctor’s instructions.

  • Often started with a low lead-in dose for 14 days to reduce the risk of rash, then increased.

• Common Side Effects:

  • Rash, nausea, fatigue, headache, abdominal pain.

  • Mild fever or muscle pain in some cases.

• Serious Concerns:

  • Severe skin reactions (like Stevens-Johnson syndrome) may occur in rare cases.

  • Liver toxicity is a significant risk, especially during the first few months of therapy—symptoms may include jaundice, dark urine, or persistent abdominal pain.

  • Blood abnormalities may also occur, requiring regular monitoring.

• Precautions:

  • Regular liver function tests are necessary.

  • Women with higher CD4 counts may have increased risk of liver-related side effects.

  • Should always be used with other HIV medicines—never alone.

  • Avoid alcohol as it increases liver strain.

• Storage: Keep in a cool, dry place, protected from moisture and light.