Ofloxacin and Ornidazole Suspension

Overview

Ofloxacin and Ornidazole Suspension is a combination medication widely used for the treatment of bacterial and protozoal infections, particularly those affecting the gastrointestinal tract.

It is commonly prescribed for diarrhea, dysentery, and other intestinal infections, especially when both bacteria and protozoa may be involved. While frequently recommended for children, adults may also be prescribed this medicine under medical supervision.

Description

• Formulation: Liquid suspension for oral use

• Route of Administration: Oral (by mouth)

• Type: Antibacterial and antiprotozoal

• Strength: Each 5 ml typically contains 50 mg Ofloxacin and 125 mg Ornidazole

• Appearance: Yellow to orange liquid suspension

Uses of Ofloxacin and Ornidazole Suspension

• Gastrointestinal infections caused by mixed bacterial and protozoal organisms

• Traveler’s diarrhea

• Amoebiasis

• Giardiasis

• Bacillary and amoebic dysentery

• Certain urinary and vaginal infections (under medical advice)

Indications

Effective against organisms such as:

• Giardia lamblia

• Entamoeba histolytica

• Escherichia coli

• Shigella

• Clostridium difficile

• Other gut pathogens

Drug Interactions

Can be taken with (if prescribed):

• Oral Rehydration Salts (ORS) – prevents dehydration

• Zinc supplements – supports recovery in children

• Probiotics – restores gut flora disrupted by antibiotics

Avoid or use with caution:

• Antacids (magnesium/aluminum) – reduce Ofloxacin absorption

• Iron or calcium supplements – may hinder absorption

• Alcohol – can cause disulfiram-like reactions (flushing, nausea, palpitations)

• NSAIDs (e.g., ibuprofen) – may increase risk of seizures

• Warfarin – may enhance anticoagulant effect

• Drugs like Cisapride, Erythromycin, Quinidine – risk of QT interval prolongation

Benefits

• Broad antimicrobial and antiprotozoal coverage

• Rapid relief from diarrhea, abdominal pain, fever, and dehydration

• Easy-to-administer liquid form, suitable for children and elderly patients

• Helps prevent complications such as dehydration and malnutrition

Possible Side Effects

• Nausea or vomiting

• Abdominal cramps

• Headache or dizziness

• Fatigue

• Dry mouth or metallic taste

• Loss of appetite

Seek immediate medical advice if severe reactions occur.

Mechanism of Action

• Ofloxacin: A fluoroquinolone that blocks bacterial enzymes (DNA gyrase and topoisomerase IV), preventing DNA replication and leading to bacterial death.

• Ornidazole: A nitroimidazole derivative that generates reactive molecules inside protozoa and anaerobic bacteria, damaging DNA and destroying the cells.

Together, they offer effective treatment against both aerobic bacteria and anaerobic protozoa, making the combination highly effective for mixed infections.

Dosage Guidelines

• Children: Typically 5 ml suspension twice daily after meals (as prescribed by doctor).

• Adults: Dose as directed by physician.

• Treatment duration: Usually 5–10 days, depending on severity and response.

Instructions for use:

• Shake bottle well before use.

• Use a calibrated spoon or oral syringe.

• Take after meals to reduce stomach upset.

• Complete the full course, even if symptoms improve.

Precautions & Safety Advice

• Do not take with dairy, antacids, or iron supplements within 2 hours of use.

• Avoid alcohol during and shortly after treatment.

• Caution in pregnancy and breastfeeding (only under doctor’s advice).

• Dose adjustments may be needed for patients with liver or kidney problems.

• Not effective for viral infections like rotavirus-induced diarrhea.

Storage Instructions

• Store below 25°C in a cool, dry place.

• Keep away from direct sunlight and moisture.

• Close bottle tightly after each use.

• Keep out of reach of children.

• Discard after expiry date or if color/odor changes.

Buy Ofloxacin and Ornidazole Suspension

Onco India International is a trusted manufacturer, supplier, exporter, and wholesaler of Ofloxacin and Ornidazole Suspension. If you are looking for high-quality formulations such as Ofloxacin and Ornidazole Suspension 50 mg/125 mg per 5 ml, feel free to contact us for reliable supply and global export.