Paracetamol Injection

Category: Analgesic and antipyretic
Form: Injectable solution for intravenous (IV) use

Uses:

• Relief of mild to moderate pain when oral or rectal administration is not possible.

• Fever reduction in patients unable to take oral medications.

• Often used postoperatively or in hospital settings for rapid analgesic and antipyretic effect.

Mechanism of Action:

• Paracetamol inhibits prostaglandin synthesis in the central nervous system.

• Reduces pain perception and fever.

• Does not have significant anti-inflammatory activity like NSAIDs.

• Acts mainly in the brain and spinal cord, rather than at peripheral sites.

Administration:

• Given as an intravenous injection or infusion, usually over 15–30 minutes.

• Dosage depends on patient weight, age, and clinical condition.

• Maximum daily dose should be observed to prevent toxicity.

Side Effects:

• Generally well tolerated.

• Rare allergic reactions (rash, itching, anaphylaxis).

• Hepatic toxicity can occur with overdose or in patients with pre-existing liver disease.

• Local reactions at injection site are uncommon.

Precautions:

• Avoid exceeding recommended daily dose to prevent liver damage.

• Use cautiously in patients with liver impairment or chronic alcohol use.

• Monitor liver function during prolonged therapy.

Summary:
Paracetamol Injection is an analgesic and antipyretic used to reduce pain and fever when oral administration is not possible. It works centrally by inhibiting prostaglandin synthesis in the brain. Administered intravenously, it is generally safe, with main risks being liver toxicity in overdose or in patients with liver disease.