Parecoxib Injection

Category: Nonsteroidal anti-inflammatory drug (NSAID), COX-2 selective inhibitor
Form: Injectable solution for intravenous (IV) or intramuscular (IM) use

Uses:

• Management of postoperative pain.

• Often used as part of multimodal analgesia to reduce the need for opioids.

• Can be used in situations where oral NSAIDs are not suitable.

Mechanism of Action:

• Parecoxib is a prodrug of valdecoxib, a selective COX-2 inhibitor.

• Inhibits cyclooxygenase-2 (COX-2) enzyme, reducing prostaglandin synthesis.

• Reduces pain and inflammation without significant inhibition of COX-1, minimizing gastrointestinal side effects compared to non-selective NSAIDs.

Administration:

• Administered as intravenous or intramuscular injection.

• Dose depends on patient age, weight, and severity of pain.

• Usually given for short-term postoperative pain management.

Side Effects:

• Cardiovascular: rare risk of hypertension, edema, or thromboembolic events.

• Gastrointestinal: nausea, dyspepsia (less common than non-selective NSAIDs).

• Other: headache, dizziness, injection site reactions.

• Renal: caution in patients with impaired kidney function.

Precautions:

• Avoid in patients with known hypersensitivity to NSAIDs or COX-2 inhibitors.

• Caution in patients with cardiovascular disease, kidney impairment, or gastrointestinal issues.

• Monitor for signs of allergic reactions during administration.

Summary:
Parecoxib Injection is a COX-2 selective NSAID used for short-term postoperative pain. It works by inhibiting prostaglandin synthesis to reduce pain and inflammation while causing fewer gastrointestinal side effects than traditional NSAIDs. Administered intravenously or intramuscularly, it is generally well tolerated, with precautions for cardiovascular, renal, and allergic risks.