Puerarin Lyophilized Injection

Category: Isoflavone-derived herbal extract / Vasodilator
Form: Lyophilized (freeze-dried) powder for reconstitution and intravenous (IV) injection

Uses:

• Cardiovascular diseases: improves blood circulation, used in angina pectoris, myocardial ischemia, and coronary heart disease.

• Cerebrovascular disorders: used for ischemic stroke, cerebral infarction, and improving cerebral blood flow.

• Diabetic complications: may improve microcirculation in diabetic patients.

• Sometimes used as adjunct therapy for hypertension or vascular dementia.

Mechanism of Action:

• Puerarin is a natural isoflavone extracted from the root of Pueraria lobata (kudzu).

• Vasodilation: relaxes vascular smooth muscle, improving blood flow.

• Antioxidant effects: reduces oxidative stress in vascular endothelial cells.

• Anti-platelet aggregation: may help prevent thrombosis.

• Improves microcirculation in heart, brain, and peripheral tissues.

Administration:

• Lyophilized powder is reconstituted with sterile water or compatible diluent before IV infusion.

• Administered intravenously over a specified period as per clinical protocol.

• Dosage depends on condition severity, patient age, and weight.

Side Effects:

• Cardiovascular: hypotension, palpitations (rare).

• Gastrointestinal: nausea, vomiting, diarrhea.

• Allergic reactions: rash, itching, or urticaria.

• Other: dizziness, headache.

• Rare: injection site reactions or anaphylactic reactions.

Precautions:

• Monitor blood pressure and heart rate during infusion.

• Use cautiously in patients with severe hypotension or heart failure.

• Avoid rapid IV injection to reduce risk of hypotension.

• Allergic history should be checked due to rare hypersensitivity reactions.

Summary:
Puerarin Lyophilized Injection is a herbal-derived vasodilator used primarily for cardiovascular and cerebrovascular disorders. It works by relaxing blood vessels, improving microcirculation, and providing antioxidant and anti-platelet effects. Administered intravenously after reconstitution, it is generally well tolerated, with side effects including mild hypotension, gastrointestinal upset, and rare allergic reactions.