Rabeprazole Injection

Category: Proton pump inhibitor (PPI)
Form: Injectable solution for intravenous (IV) use

Uses:

• Gastroesophageal reflux disease (GERD): particularly for erosive esophagitis.

• Peptic ulcer disease: including gastric and duodenal ulcers.

• Stress-related mucosal damage: prevention and treatment in critically ill patients.

• Zollinger-Ellison syndrome: to manage excessive gastric acid production.

Mechanism of Action:

• Rabeprazole irreversibly inhibits the H⁺/K⁺ ATPase (proton pump) in gastric parietal cells.

• Suppresses both basal and stimulated gastric acid secretion.

• Leads to increased gastric pH, promoting ulcer healing and reducing acid-related symptoms.

Administration:

• Administered intravenously when oral administration is not feasible.

• Dosage and infusion rate depend on the clinical condition and patient status.

• Usually given once daily in hospital or critical care settings.

Side Effects:

• Gastrointestinal: nausea, vomiting, diarrhea, constipation, abdominal pain.

• Neurological: headache, dizziness.

• Metabolic: rare electrolyte disturbances.

• Local reactions: injection site pain or irritation.

• Rare: hypersensitivity reactions or elevated liver enzymes.

Precautions:

• Use cautiously in patients with hepatic impairment.

• Monitor for electrolyte imbalances during prolonged therapy.

• Avoid rapid IV administration to prevent local irritation or hypotension.

Summary:
Rabeprazole Injection is a proton pump inhibitor used to reduce gastric acid secretion in conditions like GERD, peptic ulcers, stress ulcers, and Zollinger-Ellison syndrome. It works by blocking proton pumps in the stomach lining, increasing gastric pH. Administered intravenously when oral use is not possible, it is generally well tolerated, with side effects mainly gastrointestinal, neurological, or related to the injection site.