Rabeprazole and Itopride Capsules

At Onco India International, we manufacture and supply high-quality Rabeprazole and Itopride Capsules, a trusted combination medicine for effective management of gastric and digestive disorders.

This dual-action formulation is commonly prescribed for Gastroesophageal Reflux Disease (GERD), functional dyspepsia, and other related digestive issues.

What is Rabeprazole and Itopride?

• Rabeprazole Sodium

  • Belongs to the Proton Pump Inhibitor (PPI) group.

  • Blocks the H+/K+ ATPase enzyme system in the stomach lining.

  • Effectively reduces gastric acid production and provides long-lasting relief.

• Itopride Hydrochloride

  • A prokinetic agent that enhances stomach and bowel motility.

  • Works by blocking dopamine D2 receptors and inhibiting acetylcholinesterase.

  • Improves gastric emptying and helps reduce nausea, bloating, and discomfort.

Together, they control acidity while improving gastric motility for comprehensive digestive care.

Available Strengths

• Rabeprazole Sodium 20 mg

• Itopride Hydrochloride 150 mg

Uses of Rabeprazole and Itopride Capsules

 Relief from acid reflux and heartburn
 Treatment of indigestion, bloating, and fullness
 Improves gastric emptying
 Management of GERD and functional dyspepsia
 Reduces nausea and vomiting caused by delayed stomach emptying

Indications

• Gastroesophageal Reflux Disease (GERD)

• Functional Dyspepsia

• Chronic Gastritis

• Peptic Ulcer Disease (as adjunct therapy)

How It Works

• Rabeprazole: Inhibits stomach acid production at the final step, offering quick onset and sustained acid suppression.

• Itopride: Enhances gastric motility and accelerates gastric emptying, reducing symptoms like nausea, bloating, and heaviness.

Benefits

• Dual-action therapy: controls both acid secretion and motility disorders.

• Rapid and long-lasting symptom relief.

• Promotes healing of erosive esophagitis.

• Better patient compliance due to single combination capsule.

• Useful in certain H. pylori treatment regimens.

Side Effects

Common: Headache, diarrhea/constipation, nausea, flatulence, abdominal cramps, dizziness, dry mouth.
Serious (rare): Hypomagnesemia, Vitamin B12 deficiency, bone fractures, liver enzyme changes.

Dosage Guidelines

• Take 15–30 minutes before meals (preferably breakfast or dinner).

• Swallow whole with water; do not chew or crush.

• Typical dosage: One capsule once or twice daily (as prescribed).

• Dosage may vary based on patient condition and medical advice.

When Not to Use

• Hypersensitivity to rabeprazole, itopride, or excipients.

• Patients with GI bleeding, perforation, or obstruction.

• Severe liver impairment.

• Caution in patients with Parkinson’s disease or those on antipsychotics.

Drug Interactions

• Antifungals: Ketoconazole, Itraconazole (reduced absorption).

• Clopidogrel: May reduce antiplatelet activity.

• Warfarin: Increased bleeding risk.

• Other medicines to avoid: Digoxin, Diazepam, Methotrexate, Atazanavir, Sucralfate.

Safety Advice

• Long-term PPI use should be monitored for risks like malabsorption and fractures.

• Regular check of magnesium, vitamin B12, and liver function if taken long term.

• Elderly patients (65+) should use with caution.

• Report symptoms like GI bleeding, jaundice, or seizures immediately.

General Instructions

• Take at the same time daily for consistent results.

• Do not double dose if one is missed.

• Avoid self-medication and do not discontinue abruptly.

• Store in a cool, dry place (15–25°C) away from sunlight and moisture.

• Keep out of reach of children.

Lifestyle & Dietary Tips

• Avoid spicy, oily, and acidic foods (tomatoes, citrus).

• Limit caffeine, fizzy drinks, and chocolate.

• Eat smaller, frequent meals.

• Avoid lying down immediately after eating.

• Quit alcohol and smoking for better results.

Why Choose Onco India International?

At Onco India International, we are committed to manufacturing high-quality gastroenterology medicines with stringent quality standards, global regulatory compliance, and patient-focused formulations. Our Rabeprazole and Itopride Capsules deliver effective relief from digestive issues with proven clinical results.